Interferon (IFNγ) induces cell cycle arrest in RCC cell lines

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Interferon (IFNγ) induces cell cycle arrest in RCC cell lines

We have recently demonstrated that the anti-proliferative effect of interferon (IFNg) in RCC is due to an increased production of nitric oxide (NO) which in turn inhibits the induction of arginase (ARG2). The growth of cultured murine RCC cell lines was inhibited in 85% in IFNg treated when compared to un-treated cells. In contrast only 33% of these cells were inhibited by IFNg. These results i...

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Mechanisms of interferon-induced cell cycle arrest.

The interferons (IFNs) are a group of cytokines, which in addition to their antiviral activity are capable of modulating a variety of cellular responses. One such prominent effect of IFNs is their potent antimitogenic action, which can be observed both on malignant and non-malignant cells of many different origins. IFNs are also used in the clinic, mainly in malignant and viral diseases, and th...

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ژورنال

عنوان ژورنال: Journal for ImmunoTherapy of Cancer

سال: 2013

ISSN: 2051-1426

DOI: 10.1186/2051-1426-1-s1-p125